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All-in-one repair kit makes CRISPR gene editing more precise

For the past five years, CRISPR-Cas9 technology has revolutionized the field of gene editing due to its ease and low cost. But although this technology reliably finds and cuts the targeted stretch of DNA sequence, fixing that cut as desired has been something of a hit-or-miss process. Error rates as high as 50 percent are a particular problem when the goal is to correct typos in the DNA that cause genetic disease.

Now, a team of researchers led by Krishanu Saha, a professor of biomedical engineering at the University of Wisconsin–Madison, has made the fix less error-prone and published its approach today (Nov. 23, 2017) in the journal Nature Communications.

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