New recipes for origin of life may point way to distant, inhabited planets

Life requires repetition of chemical reactions. Describing the kinds of reactions and conditions required for self-sustaining repetition — called autocatalysis — could focus the search for life on other planets. Betül Kaçar

Life requires repetition of chemical reactions. Describing the kinds of reactions and conditions required for self-sustaining repetition — called autocatalysis — could focus the search for life on other planets. Betül Kaçar

Life on a faraway planet — if it’s out there — might not look anything like life on Earth. But there are only so many chemical ingredients in the universe’s pantry, and only so many ways to mix them. A team led by scientists at the University of Wisconsin–Madison has exploited those limitations to write a cookbook of hundreds of chemical recipes with the potential to give rise to life.

Their ingredient list could focus the search for life elsewhere in the universe by pointing out the most likely conditions — planetary versions of mixing techniques, oven temperatures and baking times — for the recipes to come together.

The process of progressing from basic chemical ingredients to the complex cycles of cell metabolism and reproduction that define life, the researchers say, requires not only a simple beginning but also repetition.

“The origin of life really is a something-from-nothing process,” says Betül Kaçar, a NASA-supported astrobiologist and UW–Madison professor of bacteriology. “But that something can’t happen just once. Life comes down to chemistry and conditions that can generate a self-reproducing pattern of reactions.”

Chemical reactions that produce molecules that encourage the same reaction to happen again and again are called autocatalytic reactions. In a new study published Sept. 18 in the Journal of the American Chemical Society, Zhen Peng, a postdoctoral researcher in the Kaçar laboratory, and collaborators compiled 270 combinations of molecules — involving atoms from all groups and series across the periodic table — with the potential for sustained autocatalysis.

“It was thought that these sorts of reactions are very rare,” says Kaçar. “We are showing that it’s actually far from rare. You just need to look in the right place.”

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